What is the Evidence of Counterpulsation?

More than 250 clinical papers have been published in peer-reviewed medical journals demonstrating Counterpulsation to be safe and effective in the treatment of angina pectoris, congestive heart failure and other cardiovascular diseases. There is a wealth of both physiological data as well as clinical outcome data that supports that Counterpulsation therapy is beneficial. The benefits of Counterpulsation are now also being explored outside of Cardiac populations including in Sports and Health and wellbeing.

Counterpulsation increases Nitric Oxide

By compressing the lower limb sequentially, Counterpulsation increases blood flow passively. This has been shown to cause a progressive increase in nitric oxide (NO) levels. NO is the most potent vasodilator, relaxing blood vessel and improving blood flow throughout the body. This is thought to explain why Counterpulsation decreases symptoms like Chest pain and also increases individuals’ ability to exercise.

Counterpulsation reduces symptoms

The precise timing of the inflation and deflation of the cuffs during treatment gives rise to two effects: Diastolic augmentation – an increase in pressure when the heart is at rest between beats, which increases blood flow. Systolic unloading – a reduction in pressure when the heart beats, thereby decreasing its workload. These actions together increase cardiac output and blood flow to the heart and to the rest of the body’s major organs.

Counterpulsation reduces episodes of chest pain and hospitalisation


A large American study demonstrated significant reductions in visits to the emergency room and patients being admitted to the the hospital with chest pain after receiving counterpulsation therapy.

Conterpulsation has long term effects on symptoms 

Another study examined the long term impact on symptoms after a single course of counterpulsation. The study found that the symptom improvement was still maintained at three years following treatment

Counterpulsation Reduces Inflammation And Stress


Counterpulsation can reduce the levels of several markers of inflammation in the blood. Studies have also found increased levels of angiogenesis (where new blood vessels are formed) markers in the blood. These findings suggest potential benefits in terms of both acute sports recovery and longer-term protective benefits to overall health.